A1CF
A1CF (APOBEC1 complementation factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.77, genetic association 0.58, somatic mutation 0.50).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · A1CF (APOBEC1 complementation factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
A1CF (APOBEC1 complementation factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA.
- 3 · How drugs use it
No product in this corpus aims at A1CF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:24086 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NQ94 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000148584 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Biology
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Location: Nucleus; Endoplasmic reticulum; Cytoplasm (UniProt). Locus 10q11.23 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"A1CF" OR ABSTRACT:"A1CF" OR TITLE:"APOBEC1 complementation factor" OR ABSTRACT:"APOBEC1 complementation factor" OR TITLE:"ACF64" OR ABSTRACT:"ACF64" OR TITLE:"ACF65" OR ABSTRACT:"ACF65" OR TITLE:"APOBEC1CF" OR ABSTRACT:"APOBEC1CF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about A1CF, not a curated reading list.