ABCB1
ABCB1 (ATP-dependent translocase ABCB1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Non-small-cell lung cancer and 1 more.
Overview
Translocates phospholipids and drugs across the membrane. Catalyses the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins.
CIViC holds 8 clinical evidence items and 0 assertions across 5 variants, naming Paclitaxel, Crizotinib, Alectinib and Dasatinib and others.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ABCB1 (ATP-dependent translocase ABCB1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Non-small-cell lung cancer and 1 more.
- 1 · What it is
ABCB1 (ATP-dependent translocase ABCB1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Ovarian cancer, Non-small-cell lung cancer and 1 more.
- 2 · What goes wrong in cancer
Translocates phospholipids and drugs across the membrane. Catalyses the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane.
- 3 · How drugs use it
No product in this corpus aims at ABCB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:40 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08183 (protein name, function text, keywords and locations (REST API)); CIViC gene ABCB1 (8 evidence items, 0 assertions, 5 variants; diseases: Lung Non-small Cell Carcinoma, Breast Cancer, Lung Adenocarcinoma, Chronic Myeloid Leukaemia, Ovarian Cancer (GraphQL API, CC0))
Biology
Translocates phospholipids and drugs across the membrane. Catalyses the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. May contribute to hepatobiliary and renal excretion of etiocholanolone-3-glucuronate. Appears to have very low activity toward testosterone, androsterone and dihydrotestosterone glucuronates. Location: Cell membrane; Apical cell membrane; Cytoplasm (UniProt). Locus 7q21.12 (HGNC).
- Breast cancer: CIViC evidence names this disease
- Ovarian cancer: CIViC evidence names this disease
- Non-small-cell lung cancer: CIViC evidence names this disease
- Chronic myeloid leukaemia: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 9 therapies; CIViC holds 8 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ABCB1" OR ABSTRACT:"ABCB1" OR TITLE:"ATP binding cassette subfamily B member 1" OR ABSTRACT:"ATP binding cassette subfamily B member 1" OR TITLE:"ATP-dependent translocase ABCB1" OR ABSTRACT:"ATP-dependent translocase ABCB1" OR TITLE:"P-gp" OR ABSTRACT:"P-gp" OR TITLE:"CD243" OR ABSTRACT:"CD243" OR TITLE:"GP170" OR ABSTRACT:"GP170") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABCB1, not a curated reading list.
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