ABCC1
ABCC1 (ATP-binding cassette sub-family C member 1) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Overview
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.84, clinical 0.12).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ABCC1 (ATP-binding cassette sub-family C member 1) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 1 · What it is
ABCC1 (ATP-binding cassette sub-family C member 1) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 2 · What goes wrong in cancer
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate.
- 3 · How drugs use it
No product in this corpus aims at ABCC1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:51 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P33527 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000103222 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: breast cancer 0.54 (GraphQL API, CC0))
Biology
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels. Mediates the systemic release of glutathione-conjugated leukotriene C4 (LTC4) from myeloid cells such as mast cells, as part of the inflammatory response. Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centres in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma. Location: Cell membrane; Basolateral cell membrane (UniProt). Locus 16p13.11 (HGNC).
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.12. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ABCC1" OR ABSTRACT:"ABCC1" OR TITLE:"ATP binding cassette subfamily C member 1 ABCC1 blood group" OR ABSTRACT:"ATP binding cassette subfamily C member 1 ABCC1 blood group" OR TITLE:"ATP-binding cassette sub-family C member 1" OR ABSTRACT:"ATP-binding cassette sub-family C member 1" OR TITLE:"GS-X" OR ABSTRACT:"GS-X" OR TITLE:"MRP1" OR ABSTRACT:"MRP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABCC1, not a curated reading list.