ABCC3
ABCC3 (ATP-binding cassette sub-family C member 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Overview
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarised cells such as hepatocytes and intestinal epithelial cells, where it mediates the efflux of conjugated substrates from intestine and liver into the bloodstream. Involved in enterohepatic recirculation of steroid glucuronates.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel and Monomethyl Auristatin E.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ABCC3 (ATP-binding cassette sub-family C member 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 1 · What it is
ABCC3 (ATP-binding cassette sub-family C member 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 2 · What goes wrong in cancer
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate.
- 3 · How drugs use it
No product in this corpus aims at ABCC3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:54 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15438 (protein name, function text, keywords and locations (REST API)); CIViC gene ABCC3 (1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0))
Biology
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyses ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarised cells such as hepatocytes and intestinal epithelial cells, where it mediates the efflux of conjugated substrates from intestine and liver into the bloodstream. Involved in enterohepatic recirculation of steroid glucuronates. Shares substrate specificity with MRP2, displaying higher affinity for both oestrogen and androgen glucuronates such as 17beta-estradiol, estrone, testosterone and 5alpha-dihydrotestosterone glucuronates. Involved in sinusoidal efflux of mono- and bis-glucuronidated bilirubin from hepatocytes into the blood for renal uptake and excretion. May selectively transport steroid sulfate conjugates. Location: Basolateral cell membrane; Basal cell membrane (UniProt). Locus 17q21.33 (HGNC).
- Breast cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ABCC3" OR ABSTRACT:"ABCC3" OR TITLE:"ATP binding cassette subfamily C member 3" OR ABSTRACT:"ATP binding cassette subfamily C member 3" OR TITLE:"ATP-binding cassette sub-family C member 3" OR ABSTRACT:"ATP-binding cassette sub-family C member 3" OR TITLE:"MRP3" OR ABSTRACT:"MRP3" OR TITLE:"cMOAT2" OR ABSTRACT:"cMOAT2" OR TITLE:"EST90757" OR ABSTRACT:"EST90757") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABCC3, not a curated reading list.