ADRM1
ADRM1 (Proteasomal ubiquitin receptor ADRM1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
Overview
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes clinical 0.99, literature 0.93, genetic association 0.00, somatic mutation 0.23, animal model 0.26).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ADRM1 (Proteasomal ubiquitin receptor ADRM1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
- 1 · What it is
ADRM1 (Proteasomal ubiquitin receptor ADRM1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma, Non-Hodgkin lymphoma and Mantle cell lymphoma.
- 2 · What goes wrong in cancer
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
- 3 · How drugs use it
No product in this corpus aims at ADRM1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:15759 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16186 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000130706 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: plasma cell myeloma 0.61, non-Hodgkin lymphoma 0.57, mantle cell lymphoma 0.54 (GraphQL API, CC0))
Biology
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. Location: Cytoplasm; Nucleus (UniProt). Locus 20q13.33 (HGNC).
- Multiple myeloma: Open Targets association 0.61 with plasma cell myeloma (MONDO_0009693)
- Non-Hodgkin lymphoma: Open Targets association 0.57 with non-Hodgkin lymphoma (MONDO_0018908)
- Mantle cell lymphoma: Open Targets association 0.54 with mantle cell lymphoma (MONDO_0018876)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ADRM1" OR ABSTRACT:"ADRM1" OR TITLE:"ADRM1 26S proteasome ubiquitin receptor" OR ABSTRACT:"ADRM1 26S proteasome ubiquitin receptor" OR TITLE:"Proteasomal ubiquitin receptor ADRM1" OR ABSTRACT:"Proteasomal ubiquitin receptor ADRM1" OR TITLE:"GP110" OR ABSTRACT:"GP110" OR TITLE:"Rpn13" OR ABSTRACT:"Rpn13" OR TITLE:"ARM1" OR ABSTRACT:"ARM1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ADRM1, not a curated reading list.
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