AGK
AGK (Acylglycerol kinase, mitochondrial) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.89, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · AGK (Acylglycerol kinase, mitochondrial) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
AGK (Acylglycerol kinase, mitochondrial) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine.
- 3 · How drugs use it
No product in this corpus aims at AGK yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:21869 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q53H12 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000006530 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide. Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol. Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force. Location: Mitochondrion inner membrane; Mitochondrion intermembrane space (UniProt). Locus 7q34 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"AGK" OR ABSTRACT:"AGK" OR TITLE:"acylglycerol kinase" OR ABSTRACT:"acylglycerol kinase" OR TITLE:"Acylglycerol kinase, mitochondrial" OR ABSTRACT:"Acylglycerol kinase, mitochondrial" OR TITLE:"FLJ10842" OR ABSTRACT:"FLJ10842") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AGK, not a curated reading list.