AGR2
AGR2 (Anterior gradient protein 2 homolog) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Overview
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Tamoxifen.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · AGR2 (Anterior gradient protein 2 homolog) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 1 · What it is
AGR2 (Anterior gradient protein 2 homolog) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells.
- 3 · How drugs use it
No product in this corpus aims at AGR2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:328 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95994 (protein name, function text, keywords and locations (REST API)); CIViC gene AGR2 (1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0))
Biology
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion. Location: Secreted; Endoplasmic reticulum (UniProt). Locus 7p21.1 (HGNC).
- Breast cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"AGR2" OR ABSTRACT:"AGR2" OR TITLE:"anterior gradient 2, protein disulphide isomerase family member" OR ABSTRACT:"anterior gradient 2, protein disulphide isomerase family member" OR TITLE:"Anterior gradient protein 2 homolog" OR ABSTRACT:"Anterior gradient protein 2 homolog" OR TITLE:"XAG-2" OR ABSTRACT:"XAG-2" OR TITLE:"HAG-2" OR ABSTRACT:"HAG-2" OR TITLE:"AG2" OR ABSTRACT:"AG2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AGR2, not a curated reading list.