ASS1
ASS1 (Argininosuccinate synthase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Sarcomas.
Overview
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyses the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Carboplatin, Cisplatin, Pegargiminase and Chloroquine and others.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ASS1 (Argininosuccinate synthase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Sarcomas.
- 1 · What it is
ASS1 (Argininosuccinate synthase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer and Sarcomas.
- 2 · What goes wrong in cancer
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals.
- 3 · How drugs use it
No product in this corpus aims at ASS1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:758 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P00966 (protein name, function text, keywords and locations (REST API)); CIViC gene ASS1 (2 evidence items, 0 assertions, 2 variants; diseases: Ovarian Cancer, Sarcoma (GraphQL API, CC0))
Biology
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyses the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. Location: Cytoplasm, cytosol (UniProt). Locus 9q34.11 (HGNC).
- Ovarian cancer: CIViC evidence names this disease
- Sarcomas: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ASS1" OR ABSTRACT:"ASS1" OR TITLE:"argininosuccinate synthase 1" OR ABSTRACT:"argininosuccinate synthase 1" OR TITLE:"Argininosuccinate synthase" OR ABSTRACT:"Argininosuccinate synthase" OR TITLE:"CTLN1" OR ABSTRACT:"CTLN1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ASS1, not a curated reading list.