ATP7B
ATP7B (Copper-transporting ATPase 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Overview
Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
CIViC holds 4 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin, Tranilast, Telmisartan and Amphotericin B.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ATP7B (Copper-transporting ATPase 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
- 1 · What it is
ATP7B (Copper-transporting ATPase 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
- 2 · What goes wrong in cancer
Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
- 3 · How drugs use it
No product in this corpus aims at ATP7B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:870 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35670 (protein name, function text, keywords and locations (REST API)); CIViC gene ATP7B (4 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0))
Biology
Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. Location: Golgi apparatus, trans-Golgi network membrane; Late endosome; Golgi apparatus membrane; Cytoplasm (UniProt). Locus 13q14.3 (HGNC).
- Ovarian cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ATP7B" OR ABSTRACT:"ATP7B" OR TITLE:"ATPase copper transporting beta" OR ABSTRACT:"ATPase copper transporting beta" OR TITLE:"Copper-transporting ATPase 2" OR ABSTRACT:"Copper-transporting ATPase 2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATP7B, not a curated reading list.