BIK
BIK (Bcl-2-interacting killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.64).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BIK (Bcl-2-interacting killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
BIK (Bcl-2-interacting killer) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity.
- 3 · How drugs use it
No product in this corpus aims at BIK yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1051 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13323 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100290 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: prostate cancer 0.50 (GraphQL API, CC0))
Biology
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. Location: Endomembrane system; Mitochondrion membrane (UniProt). Locus 22q13.2 (HGNC).
- Prostate cancer: Open Targets association 0.50 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BIK" OR ABSTRACT:"BIK" OR TITLE:"BCL2 interacting killer" OR ABSTRACT:"BCL2 interacting killer" OR TITLE:"Bcl-2-interacting killer" OR ABSTRACT:"Bcl-2-interacting killer") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BIK, not a curated reading list.