BIRC7
BIRC7 (Baculoviral IAP repeat-containing protein 7) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Overview
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BIRC7 (Baculoviral IAP repeat-containing protein 7) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 1 · What it is
BIRC7 (Baculoviral IAP repeat-containing protein 7) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control.
- 3 · How drugs use it
No product in this corpus aims at BIRC7 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:13702 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96CA5 (protein name, function text, keywords and locations (REST API)); CIViC gene BIRC7 (2 evidence items, 0 assertions, 1 variants; diseases: Colon Cancer, Papillary Thyroid Carcinoma (GraphQL API, CC0))
Biology
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. Location: Nucleus; Cytoplasm; Golgi apparatus (UniProt). Locus 20q13.33 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Papillary Thyroid Carcinoma.
Latest papers
topQuery for this target: (TITLE:"BIRC7" OR ABSTRACT:"BIRC7" OR TITLE:"baculoviral IAP repeat containing 7" OR ABSTRACT:"baculoviral IAP repeat containing 7" OR TITLE:"Baculoviral IAP repeat-containing protein 7" OR ABSTRACT:"Baculoviral IAP repeat-containing protein 7" OR TITLE:"mliap" OR ABSTRACT:"mliap" OR TITLE:"ML-IAP" OR ABSTRACT:"ML-IAP" OR TITLE:"RNF50" OR ABSTRACT:"RNF50") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BIRC7, not a curated reading list.