CCDC88C
CCDC88C (coiled-coil and HOOK domain protein 88C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signalling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.70, animal model 0.74, genetic association 0.64).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CCDC88C (coiled-coil and HOOK domain protein 88C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CCDC88C (coiled-coil and HOOK domain protein 88C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling.
- 3 · How drugs use it
No product in this corpus aims at CCDC88C yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:19967 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9P219 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000015133 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signalling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signalling. Promotes apical constriction of cells via ARHGEF18. Location: Cytoplasm; Cell junction (UniProt). Locus 14q32.11-q32.12 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CCDC88C" OR ABSTRACT:"CCDC88C" OR TITLE:"coiled-coil and HOOK domain protein 88C" OR ABSTRACT:"coiled-coil and HOOK domain protein 88C" OR TITLE:"DAPLE" OR ABSTRACT:"DAPLE" OR TITLE:"HkRP2" OR ABSTRACT:"HkRP2" OR TITLE:"SCA40" OR ABSTRACT:"SCA40" OR TITLE:"KIAA1509" OR ABSTRACT:"KIAA1509") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCDC88C, not a curated reading list.