CD200
CD200 (OX-2 membrane glycoprotein) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.61, clinical 0.15).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CD200 (OX-2 membrane glycoprotein) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
CD200 (OX-2 membrane glycoprotein) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
- 3 · How drugs use it
No product in this corpus aims at CD200 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7203 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P41217 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000091972 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Biology
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. Location: Cell membrane (UniProt). Locus 3q13.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.15. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CD200" OR ABSTRACT:"CD200" OR TITLE:"CD200 molecule" OR ABSTRACT:"CD200 molecule" OR TITLE:"OX-2 membrane glycoprotein" OR ABSTRACT:"OX-2 membrane glycoprotein" OR TITLE:"OX-2" OR ABSTRACT:"OX-2" OR TITLE:"MOX1" OR ABSTRACT:"MOX1" OR TITLE:"MOX2" OR ABSTRACT:"MOX2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD200, not a curated reading list.