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CD34 marks the blood-forming stem cells that a transplant is counted in, and it also stains blood vessels, which is how new vessel growth in a tumour is measured.
CD34 is a sialomucin carried by haematopoietic stem and progenitor cells and by vascular endothelium. It is one of the few markers with a direct clinical count attached: a stem cell graft is dosed in CD34-positive cells per kilogram, which decides whether an autologous or allogeneic transplant can go ahead. Its second use is as an endothelial stain for measuring microvessel density, the standard histological read-out for angiogenesis in a tumour.
In plain words · CD34 marks the blood-forming stem cells that a transplant is counted in, and it also stains blood vessels, which is how new vessel growth in a tumour is measured.
CD34 marks the blood-forming stem cells that a transplant is counted in, and it also stains blood vessels, which is how new vessel growth in a tumour is measured.
Sialomucin adhesion molecule on haematopoietic stem and progenitor cells and on vascular endothelium.
No product in this corpus aims at CD34 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Sialomucin adhesion molecule on haematopoietic stem and progenitor cells and on vascular endothelium.
Query for this target: (TITLE:"CD34" OR ABSTRACT:"CD34") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD34, not a curated reading list.
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