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CD62L is the ticket a lymphocyte needs to get into a lymph node. Whether a T cell carries it separates the cells held in reserve from the ones already out working in tissue.
CD62L is L-selectin, the adhesion receptor that lets a lymphocyte roll along and enter the high endothelial venules of a lymph node. Its presence or absence, read with CCR7, is how naive and central memory cells are told apart from effector memory cells that have left the lymph node circuit for tissue. That distinction is central to cell therapy, where the less differentiated, CD62L-carrying populations are the ones that persist and expand after infusion.
In plain words · CD62L is the ticket a lymphocyte needs to get into a lymph node. Whether a T cell carries it separates the cells held in reserve from the ones already out working in tissue.
CD62L is the ticket a lymphocyte needs to get into a lymph node. Whether a T cell carries it separates the cells held in reserve from the ones already out working in tissue.
L-selectin, the homing receptor that lets lymphocytes enter a lymph node across its high endothelial venules.
No product in this corpus aims at CD62L yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
L-selectin, the homing receptor that lets lymphocytes enter a lymph node across its high endothelial venules.
Query for this target: (TITLE:"CD62L" OR ABSTRACT:"CD62L" OR TITLE:"SELL" OR ABSTRACT:"SELL" OR TITLE:"L-selectin" OR ABSTRACT:"L-selectin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD62L, not a curated reading list.
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