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CD69 appears within hours of a lymphocyte being activated, so it is the quickest way to tell that something has just woken the immune system up. It also keeps T cells inside a tissue rather than letting them drift back to the blood.
CD69 is the earliest surface antigen induced after lymphocyte activation, appearing within hours, which makes it the standard readout for a response that has just happened rather than one that happened weeks ago. It has a second job: by opposing sphingosine-1-phosphate receptor 1 it keeps cells from leaving a tissue, and so it is one of the markers that define tissue-resident memory T cells, the population that stays inside an organ, including inside a tumour.
In plain words · CD69 appears within hours of a lymphocyte being activated, so it is the quickest way to tell that something has just woken the immune system up. It also keeps T cells inside a tissue rather than letting them drift back to the blood.
CD69 appears within hours of a lymphocyte being activated, so it is the quickest way to tell that something has just woken the immune system up. It also keeps T cells inside a tissue rather than letting them drift back to the blood.
Earliest inducible surface antigen after lymphocyte activation; also retains cells in tissue by opposing S1P receptor 1.
No product in this corpus aims at CD69 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Earliest inducible surface antigen after lymphocyte activation; also retains cells in tissue by opposing S1P receptor 1.
Query for this target: (TITLE:"CD69" OR ABSTRACT:"CD69") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD69, not a curated reading list.
Shares T-cell exhaustion and CAR-T persistence, T cell and the tag immune-marker.
Shares T-cell exhaustion and CAR-T persistence and the tag immune-marker.
Shares T cell and the tag immune-marker.
Shares T cell and the tag immune-marker.
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