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CD57 appears on immune cells that have divided many times and are near the end of their working life. It is the usual way of telling a worn-out T cell from a fresh one.
CD57 is the carbohydrate epitope made by the glucuronyltransferase B3GAT1, and it accumulates on lymphocytes that have gone through many rounds of division. It marks terminal differentiation and replicative senescence rather than exhaustion proper, and the distinction matters: a senescent cell has run out of divisions, whereas an exhausted cell is being actively restrained by checkpoints and may be released by blocking them. CD57 is usually read alongside the loss of CD28, and on natural killer cells it marks the most mature, most cytotoxic population.
In plain words · CD57 appears on immune cells that have divided many times and are near the end of their working life. It is the usual way of telling a worn-out T cell from a fresh one.
CD57 appears on immune cells that have divided many times and are near the end of their working life. It is the usual way of telling a worn-out T cell from a fresh one.
Glucuronyltransferase making the HNK-1 carbohydrate epitope; accumulates on repeatedly divided lymphocytes.
No product in this corpus aims at CD57 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Glucuronyltransferase making the HNK-1 carbohydrate epitope; accumulates on repeatedly divided lymphocytes.
Query for this target: (TITLE:"CD57" OR ABSTRACT:"CD57" OR TITLE:"B3GAT1" OR ABSTRACT:"B3GAT1" OR TITLE:"HNK-1" OR ABSTRACT:"HNK-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD57, not a curated reading list.
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