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CXCR3 is the receptor a killer T cell uses to find its way into a tumour. If the tumour is not making the signals it listens for, the T cells never arrive, which is one way a tumour stays cold.
CXCR3 binds the interferon-induced chemokines CXCL9, CXCL10 and CXCL11, and it is the receptor that steers effector T cells towards inflamed tissue. It is the mechanical link between the interferon-gamma signature and T cell infiltration: a tumour that does not produce those chemokines is not entered by the cells that could kill it, which is one of the described routes to immune exclusion and a cold tumour.
In plain words · CXCR3 is the receptor a killer T cell uses to find its way into a tumour. If the tumour is not making the signals it listens for, the T cells never arrive, which is one way a tumour stays cold.
CXCR3 is the receptor a killer T cell uses to find its way into a tumour. If the tumour is not making the signals it listens for, the T cells never arrive, which is one way a tumour stays cold.
Chemokine receptor for CXCL9, CXCL10 and CXCL11; guides effector T cells towards interferon-driven inflammation.
No product in this corpus aims at CXCR3 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Chemokine receptor for CXCL9, CXCL10 and CXCL11; guides effector T cells towards interferon-driven inflammation.
Query for this target: (TITLE:"CXCR3" OR ABSTRACT:"CXCR3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CXCR3, not a curated reading list.
Shares CD8 and the tag immune-marker.
Shares CD8 and the tag immune-marker.
Shares Immune exclusion, Hot vs cold tumours.
Shares CD8, Hot vs cold tumours.
Shares Immune exclusion, Hot vs cold tumours.
Shares Immune exclusion, Hot vs cold tumours.
Shares Immune exclusion, Hot vs cold tumours.
Shares Immune exclusion, Hot vs cold tumours.
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