CLCN6
CLCN6 (H(+)/Cl(-) exchange transporter 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.16, affected pathway 0.89, genetic association 0.05).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CLCN6 (H(+)/Cl(-) exchange transporter 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CLCN6 (H(+)/Cl(-) exchange transporter 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen.
- 3 · How drugs use it
No product in this corpus aims at CLCN6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2024 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51797 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000011021 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Biology
Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. Location: Late endosome membrane (UniProt). Locus 1p36.22 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CLCN6" OR ABSTRACT:"CLCN6" OR TITLE:"Cl-/H+ antiporter 6" OR ABSTRACT:"Cl-/H+ antiporter 6" OR TITLE:"H + /Cl - exchange transporter 6" OR ABSTRACT:"H + /Cl - exchange transporter 6" OR TITLE:"CLC-6" OR ABSTRACT:"CLC-6" OR TITLE:"KIAA0046" OR ABSTRACT:"KIAA0046" OR TITLE:"ClC-6" OR ABSTRACT:"ClC-6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLCN6, not a curated reading list.