CLPTM1L
CLPTM1L (Lipid scramblase CLPTM1L) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.95, animal model 0.30, genetic association 0.63, somatic mutation 0.23).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CLPTM1L (Lipid scramblase CLPTM1L) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CLPTM1L (Lipid scramblase CLPTM1L) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI).
- 3 · How drugs use it
No product in this corpus aims at CLPTM1L yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:24308 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96KA5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000049656 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro. Location: Endoplasmic reticulum membrane (UniProt). Locus 5p15.33 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CLPTM1L" OR ABSTRACT:"CLPTM1L" OR TITLE:"CLPTM1 like" OR ABSTRACT:"CLPTM1 like" OR TITLE:"Lipid scramblase CLPTM1L" OR ABSTRACT:"Lipid scramblase CLPTM1L" OR TITLE:"FLJ14400" OR ABSTRACT:"FLJ14400" OR TITLE:"CRR9" OR ABSTRACT:"CRR9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLPTM1L, not a curated reading list.