CREB3L1
CREB3L1 (Cyclic AMP-responsive element-binding protein 3-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas, Lung cancer and Breast cancer.
Overview
Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CREB3L1 (Cyclic AMP-responsive element-binding protein 3-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas, Lung cancer and Breast cancer.
- 1 · What it is
CREB3L1 (Cyclic AMP-responsive element-binding protein 3-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas, Lung cancer and Breast cancer.
- 2 · What goes wrong in cancer
Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane.
- 3 · How drugs use it
No product in this corpus aims at CREB3L1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:18856 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96BA8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000157613 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: sarcoma 0.59, breast cancer 0.51, lung cancer 0.51 (GraphQL API, CC0))
Biology
Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition. Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3'. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Location: Endoplasmic reticulum membrane; Nucleus (UniProt). Locus 11p11.2 (HGNC).
- Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
- Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CREB3L1" OR ABSTRACT:"CREB3L1" OR TITLE:"cAMP responsive element binding protein 3 like 1" OR ABSTRACT:"cAMP responsive element binding protein 3 like 1" OR TITLE:"Cyclic AMP-responsive element-binding protein 3-like protein 1" OR ABSTRACT:"Cyclic AMP-responsive element-binding protein 3-like protein 1" OR TITLE:"OASIS" OR ABSTRACT:"OASIS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CREB3L1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetCREB3L2
Shares Lung cancer (all types), Sarcomas (soft tissue, bone, GIST), Breast cancer (all types), Open Targets Platform.
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Shares Lung cancer (all types), Breast cancer (all types), Open Targets Platform.
- TargetNDRG1
Shares Lung cancer (all types), Breast cancer (all types), Open Targets Platform.
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