CRKL
CRKL (Crk-like protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.
Overview
May mediate the transduction of intracellular signals.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Gefitinib and Dasatinib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CRKL (Crk-like protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.
- 1 · What it is
CRKL (Crk-like protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
May mediate the transduction of intracellular signals. Locus 22q11.21 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at CRKL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2363 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P46109 (protein name, function text, keywords and locations (REST API)); CIViC gene CRKL (2 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma, Stomach Cancer (GraphQL API, CC0))
Biology
May mediate the transduction of intracellular signals. Locus 22q11.21 (HGNC).
- Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease
- Non-small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CRKL" OR ABSTRACT:"CRKL" OR TITLE:"CRK like proto-oncogene, adaptor protein" OR ABSTRACT:"CRK like proto-oncogene, adaptor protein" OR TITLE:"Crk-like protein" OR ABSTRACT:"Crk-like protein") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CRKL, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetRB1
- TargetCDKN2A
- TargetMEK1/2
Shares Chronic myeloid leukaemia (KEGG map), Non-small-cell lung cancer.