CXCL10
CXCL10 (C-X-C motif chemokine 10) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Osteosarcoma.
Overview
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signalling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganisation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CXCL10 (C-X-C motif chemokine 10) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Osteosarcoma.
- 1 · What it is
CXCL10 (C-X-C motif chemokine 10) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Osteosarcoma.
- 2 · What goes wrong in cancer
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects.
- 3 · How drugs use it
No product in this corpus aims at CXCL10 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10637 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02778 (protein name, function text, keywords and locations (REST API)); CIViC gene CXCL10 (1 evidence items, 0 assertions, 1 variants; diseases: Osteosarcoma (GraphQL API, CC0))
Biology
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signalling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganisation. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganisation. Location: Secreted (UniProt). Locus 4q21.1 (HGNC).
- Osteosarcoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CXCL10" OR ABSTRACT:"CXCL10" OR TITLE:"C-X-C motif chemokine ligand 10" OR ABSTRACT:"C-X-C motif chemokine ligand 10" OR TITLE:"C-X-C motif chemokine 10" OR ABSTRACT:"C-X-C motif chemokine 10" OR TITLE:"IFI10" OR ABSTRACT:"IFI10" OR TITLE:"IP-10" OR ABSTRACT:"IP-10" OR TITLE:"crg-2" OR ABSTRACT:"crg-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CXCL10, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetTBK1
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- TargetZNF217
Shares Osteosarcoma, CIViC.
- TargetERCC2
Shares Osteosarcoma, CIViC.