DDX5
DDX5 (Probable ATP-dependent RNA helicase DDX5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Skin cancer.
Overview
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.96).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DDX5 (Probable ATP-dependent RNA helicase DDX5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Skin cancer.
- 1 · What it is
DDX5 (Probable ATP-dependent RNA helicase DDX5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Skin cancer.
- 2 · What goes wrong in cancer
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner.
- 3 · How drugs use it
No product in this corpus aims at DDX5 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:2746 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17844 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108654 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: colorectal cancer 0.53, skin cancer 0.51 (GraphQL API, CC0))
Biology
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergises with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Location: Nucleus; Nucleus, nucleolus; Nucleus speckle; Cytoplasm (UniProt). Locus 17q23.3 (HGNC).
- Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DDX5" OR ABSTRACT:"DDX5" OR TITLE:"DEAD-box helicase 5" OR ABSTRACT:"DEAD-box helicase 5" OR TITLE:"Probable ATP-dependent RNA helicase DDX5" OR ABSTRACT:"Probable ATP-dependent RNA helicase DDX5" OR TITLE:"p68" OR ABSTRACT:"p68" OR TITLE:"HLR1" OR ABSTRACT:"HLR1" OR TITLE:"G17P1" OR ABSTRACT:"G17P1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDX5, not a curated reading list.