DLL4
DLL4 (Delta-like protein 4) is a protein on the cell surface. The public catalogues list it as a drug target and an antigen, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Involved in the Notch signalling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes clinical 0.18, affected pathway 0.91, literature 0.98, genetic association 0.00, animal model 0.26). In OnCo, 1 product record names it (Tovecimig).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DLL4 (Delta-like protein 4) is a protein on the cell surface. The public catalogues list it as a drug target and an antigen, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
DLL4 (Delta-like protein 4) is a protein on the cell surface. The public catalogues list it as a drug target and an antigen, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Involved in the Notch signalling pathway as Notch ligand. Activates NOTCH1 and NOTCH4.
- 3 · How drugs use it
No product in this corpus aims at DLL4 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
External identifiers
Sources: HGNC HGNC:2910 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NR61 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000128917 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Biology
Involved in the Notch signalling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. Location: Cell membrane (UniProt). Locus 15q15.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.18; a membrane or secreted protein (UniProt keywords) that 1 antibody-based OnCo product name. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DLL4" OR ABSTRACT:"DLL4" OR TITLE:"delta like canonical Notch ligand 4" OR ABSTRACT:"delta like canonical Notch ligand 4" OR TITLE:"Delta-like protein 4" OR ABSTRACT:"Delta-like protein 4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DLL4, not a curated reading list.