DNA2
DNA2 (DNA replication ATP-dependent helicase/nuclease DNA2) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Overview
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.87, genetic association 0.03).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DNA2 (DNA replication ATP-dependent helicase/nuclease DNA2) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 1 · What it is
DNA2 (DNA replication ATP-dependent helicase/nuclease DNA2) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion.
- 3 · How drugs use it
No product in this corpus aims at DNA2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:2939 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51530 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138346 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. Location: Nucleus; Mitochondrion (UniProt). Locus 10q21.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DNA2" OR ABSTRACT:"DNA2" OR TITLE:"DNA replication helicase/nuclease 2" OR ABSTRACT:"DNA replication helicase/nuclease 2" OR TITLE:"DNA replication ATP-dependent helicase/nuclease DNA2" OR ABSTRACT:"DNA replication ATP-dependent helicase/nuclease DNA2" OR TITLE:"KIAA0083" OR ABSTRACT:"KIAA0083" OR TITLE:"DNA2L" OR ABSTRACT:"DNA2L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNA2, not a curated reading list.