DNAJC1
DNAJC1 (DnaJ homolog subfamily C member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
May modulate protein synthesis.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.71, genetic association 0.65).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DNAJC1 (DnaJ homolog subfamily C member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
DNAJC1 (DnaJ homolog subfamily C member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May modulate protein synthesis. Location: Endoplasmic reticulum membrane; Nucleus membrane; Microsome membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at DNAJC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:20090 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96KC8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136770 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
May modulate protein synthesis. Location: Endoplasmic reticulum membrane; Nucleus membrane; Microsome membrane (UniProt). Locus 10p12.31 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DNAJC1" OR ABSTRACT:"DNAJC1" OR TITLE:"DnaJ heat shock protein family Hsp40 member C1" OR ABSTRACT:"DnaJ heat shock protein family Hsp40 member C1" OR TITLE:"DnaJ homolog subfamily C member 1" OR ABSTRACT:"DnaJ homolog subfamily C member 1" OR TITLE:"DNAJL1" OR ABSTRACT:"DNAJL1" OR TITLE:"ERdj1" OR ABSTRACT:"ERdj1" OR TITLE:"MTJ1" OR ABSTRACT:"MTJ1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNAJC1, not a curated reading list.