ELAC2
ELAC2 (Zinc phosphodiesterase ELAC protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.74, animal model 0.70, genetic association 0.84, genetic literature 0.61).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ELAC2 (Zinc phosphodiesterase ELAC protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
ELAC2 (Zinc phosphodiesterase ELAC protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
- 3 · How drugs use it
No product in this corpus aims at ELAC2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:14198 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BQ52 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000006744 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: prostate cancer 0.74 (GraphQL API, CC0))
Biology
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. Location: Mitochondrion; Mitochondrion matrix, mitochondrion nucleoid; Nucleus (UniProt). Locus 17p12 (HGNC).
- Prostate cancer: Open Targets association 0.74 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ELAC2" OR ABSTRACT:"ELAC2" OR TITLE:"elaC ribonuclease Z 2" OR ABSTRACT:"elaC ribonuclease Z 2" OR TITLE:"Zinc phosphodiesterase ELAC protein 2" OR ABSTRACT:"Zinc phosphodiesterase ELAC protein 2" OR TITLE:"FLJ10530" OR ABSTRACT:"FLJ10530" OR TITLE:"HPC2" OR ABSTRACT:"HPC2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ELAC2, not a curated reading list.