ERC1
ERC1 (ELKS/Rab6-interacting/CAST family member 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.38, animal model 0.42, genetic association 0.08, somatic mutation 0.92).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ERC1 (ELKS/Rab6-interacting/CAST family member 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
ERC1 (ELKS/Rab6-interacting/CAST family member 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex.
- 3 · How drugs use it
No product in this corpus aims at ERC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17072 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IUD2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000082805 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Biology
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm; Membrane; Golgi apparatus membrane (UniProt). Locus 12p13.33 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ERC1" OR ABSTRACT:"ERC1" OR TITLE:"ELKS/RAB6-interacting/CAST family member 1" OR ABSTRACT:"ELKS/RAB6-interacting/CAST family member 1" OR TITLE:"ELKS/Rab6-interacting/CAST family member 1" OR ABSTRACT:"ELKS/Rab6-interacting/CAST family member 1" OR TITLE:"KIAA1081" OR ABSTRACT:"KIAA1081" OR TITLE:"CAST2" OR ABSTRACT:"CAST2" OR TITLE:"MGC12974" OR ABSTRACT:"MGC12974") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERC1, not a curated reading list.