ERCC6
ERCC6 (Chimeric ERCC6-PGBD3 protein) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.
Overview
Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Fluorouracil. Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.61, animal model 0.47, genetic association 0.91).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ERCC6 (Chimeric ERCC6-PGBD3 protein) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.
- 1 · What it is
ERCC6 (Chimeric ERCC6-PGBD3 protein) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.
- 2 · What goes wrong in cancer
Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression.
- 3 · How drugs use it
No product in this corpus aims at ERCC6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3438 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P0DP91 (protein name, function text, keywords and locations (REST API)); CIViC gene ERCC6 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0)); Open Targets ENSG00000225830 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: lung cancer 0.57 (GraphQL API, CC0))
Biology
Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterised by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. Location: Nucleus (UniProt). Locus 10q11.23 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
- Lung cancer: Open Targets association 0.57 with lung cancer (MONDO_0008903)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ERCC6" OR ABSTRACT:"ERCC6" OR TITLE:"ERCC excision repair 6, chromatin remodeling factor" OR ABSTRACT:"ERCC excision repair 6, chromatin remodeling factor" OR TITLE:"Chimeric ERCC6-PGBD3 protein" OR ABSTRACT:"Chimeric ERCC6-PGBD3 protein" OR TITLE:"RAD26" OR ABSTRACT:"RAD26" OR TITLE:"ARMD5" OR ABSTRACT:"ARMD5" OR TITLE:"CKN2" OR ABSTRACT:"CKN2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERCC6, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetPOU5F1
Shares Lung cancer (all types), CIViC, Open Targets Platform, Colorectal cancer.
- TargetPRKN
Shares Lung cancer (all types), CIViC, Open Targets Platform.
- TargetTPM3
Shares Lung cancer (all types), Open Targets Platform, Colorectal cancer.
- TargetRSPO3
Shares Lung cancer (all types), Open Targets Platform, Colorectal cancer.
- TargetNR4A3
Shares Lung cancer (all types), CIViC, Open Targets Platform, Colorectal cancer.
- TargetAIMP2
Shares Lung cancer (all types), CIViC.
- TargetPDCD4
Shares Lung cancer (all types), CIViC.
- TargetTP53BP1
Shares Lung cancer (all types), CIViC.