ESRP1
ESRP1 (Epithelial splicing regulatory protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT).
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.89, animal model 0.64, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ESRP1 (Epithelial splicing regulatory protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
ESRP1 (Epithelial splicing regulatory protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2.
- 3 · How drugs use it
No product in this corpus aims at ESRP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:25966 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6NXG1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104413 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Biology
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium. Location: Nucleus (UniProt). Locus 8q22.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ESRP1" OR ABSTRACT:"ESRP1" OR TITLE:"epithelial splicing regulatory protein 1" OR ABSTRACT:"epithelial splicing regulatory protein 1" OR TITLE:"Epithelial splicing regulatory protein 1" OR ABSTRACT:"Epithelial splicing regulatory protein 1" OR TITLE:"FLJ20171" OR ABSTRACT:"FLJ20171" OR TITLE:"RBM35A" OR ABSTRACT:"RBM35A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ESRP1, not a curated reading list.