EXT2
EXT2 (Exostosin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Ovarian cancer, Skin cancer and Breast cancer.
Overview
Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyses the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity.
Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.84, affected pathway 0.25, genetic association 0.64, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EXT2 (Exostosin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Ovarian cancer, Skin cancer and Breast cancer.
- 1 · What it is
EXT2 (Exostosin-2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Ovarian cancer, Skin cancer and Breast cancer.
- 2 · What goes wrong in cancer
Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyses the elongation of the heparan sulfate glycan backbone.
- 3 · How drugs use it
No product in this corpus aims at EXT2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:3513 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q93063 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000151348 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: ovarian cancer 0.57, skin cancer 0.51, breast cancer 0.50 (GraphQL API, CC0))
Biology
Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyses the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signalling. Location: Golgi apparatus membrane; Golgi apparatus, cis-Golgi network membrane; Endoplasmic reticulum membrane; Secreted (UniProt). Locus 11p11.2 (HGNC).
- Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.50 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EXT2" OR ABSTRACT:"EXT2" OR TITLE:"exostosin glycosyltransferase 2" OR ABSTRACT:"exostosin glycosyltransferase 2" OR TITLE:"Exostosin-2" OR ABSTRACT:"Exostosin-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EXT2, not a curated reading list.