FAAP20
FAAP20 (Fanconi anaemia core complex-associated protein 20) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Component of the Fanconi anaemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognises and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Interventional Radiology Procedure and PARP Inhibitor AZD2461.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FAAP20 (Fanconi anaemia core complex-associated protein 20) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
FAAP20 (Fanconi anaemia core complex-associated protein 20) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Component of the Fanconi anaemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair.
- 3 · How drugs use it
No product in this corpus aims at FAAP20 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:26428 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6NZ36 (protein name, function text, keywords and locations (REST API)); CIViC gene FAAP20 (2 evidence items, 0 assertions, 1 variants; diseases: Cancer (GraphQL API, CC0))
Biology
Component of the Fanconi anaemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognises and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. Location: Nucleus; Chromosome (UniProt). Locus 1p36.33 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FAAP20" OR ABSTRACT:"FAAP20" OR TITLE:"FA core complex associated protein 20" OR ABSTRACT:"FA core complex associated protein 20" OR TITLE:"Fanconi anemia core complex-associated protein 20" OR ABSTRACT:"Fanconi anemia core complex-associated protein 20" OR TITLE:"FLJ31031" OR ABSTRACT:"FLJ31031" OR TITLE:"C1orf86" OR ABSTRACT:"C1orf86") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAAP20, not a curated reading list.