FDPS
FDPS (Farnesyl pyrophosphate synthase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Multiple myeloma and Breast cancer.
Overview
Key enzyme in isoprenoid biosynthesis which catalyses the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyses the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.86, genetic association 0.00, clinical 0.99).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FDPS (Farnesyl pyrophosphate synthase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Multiple myeloma and Breast cancer.
- 1 · What it is
FDPS (Farnesyl pyrophosphate synthase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Multiple myeloma and Breast cancer.
- 2 · What goes wrong in cancer
Key enzyme in isoprenoid biosynthesis which catalyses the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones.
- 3 · How drugs use it
No product in this corpus aims at FDPS yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:3631 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P14324 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000160752 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: prostate cancer 0.60, plasma cell myeloma 0.60, breast cancer 0.54 (GraphQL API, CC0))
Biology
Key enzyme in isoprenoid biosynthesis which catalyses the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyses the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Location: Cytoplasm (UniProt). Locus 1q22 (HGNC).
- Prostate cancer: Open Targets association 0.60 with prostate cancer (MONDO_0008315)
- Multiple myeloma: Open Targets association 0.60 with plasma cell myeloma (MONDO_0009693)
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FDPS" OR ABSTRACT:"FDPS" OR TITLE:"farnesyl diphosphate synthase" OR ABSTRACT:"farnesyl diphosphate synthase" OR TITLE:"Farnesyl pyrophosphate synthase" OR ABSTRACT:"Farnesyl pyrophosphate synthase") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FDPS, not a curated reading list.