FEV
FEV (FEV transcription factor, ETS family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.67, genetic association 0.00, somatic mutation 0.92).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FEV (FEV transcription factor, ETS family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
FEV (FEV transcription factor, ETS family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor.
- 3 · How drugs use it
No product in this corpus aims at FEV yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:18562 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99581 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163497 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Biology
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. Location: Nucleus (UniProt). Locus 2q35 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FEV" OR ABSTRACT:"FEV" OR TITLE:"FEV transcription factor, ETS family member" OR ABSTRACT:"FEV transcription factor, ETS family member" OR TITLE:"Pet-1" OR ABSTRACT:"Pet-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FEV, not a curated reading list.