FGF10
FGF10 (Fibroblast growth factor 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes affected pathway 0.97, literature 0.91, genetic association 0.78, somatic mutation 0.61, animal model 0.90).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FGF10 (Fibroblast growth factor 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
FGF10 (Fibroblast growth factor 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis.
- 3 · How drugs use it
No product in this corpus aims at FGF10 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3666 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15520 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000070193 (association with cancer (MONDO_0004992) 0.76; (GraphQL API, CC0))
Biology
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Location: Secreted (UniProt). Locus 5p12 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FGF10" OR ABSTRACT:"FGF10" OR TITLE:"fibroblast growth factor 10" OR ABSTRACT:"fibroblast growth factor 10" OR TITLE:"Fibroblast growth factor 10" OR ABSTRACT:"Fibroblast growth factor 10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF10, not a curated reading list.