FGF13
FGF13 (Fibroblast growth factor 13) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Overview
Microtubule-binding protein which directly binds tubulin and is involved in both polymerisation and stabilisation of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarisation and migration in the cerebral cortex and the hippocampus.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FGF13 (Fibroblast growth factor 13) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 1 · What it is
FGF13 (Fibroblast growth factor 13) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Microtubule-binding protein which directly binds tubulin and is involved in both polymerisation and stabilisation of microtubules.
- 3 · How drugs use it
No product in this corpus aims at FGF13 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3670 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92913 (protein name, function text, keywords and locations (REST API)); CIViC gene FGF13 (1 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer (GraphQL API, CC0))
Biology
Microtubule-binding protein which directly binds tubulin and is involved in both polymerisation and stabilisation of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarisation and migration in the cerebral cortex and the hippocampus. Regulates voltage-gated sodium channel transport and function. May also play a role in MAPK signalling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons. Location: Nucleus; Cytoplasm; Cell projection, filopodium; Cell projection, growth cone (UniProt). Locus Xq26.3-q27.1 (HGNC).
- Prostate cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FGF13" OR ABSTRACT:"FGF13" OR TITLE:"fibroblast growth factor 13" OR ABSTRACT:"fibroblast growth factor 13" OR TITLE:"Fibroblast growth factor 13" OR ABSTRACT:"Fibroblast growth factor 13" OR TITLE:"FHF2" OR ABSTRACT:"FHF2" OR TITLE:"FGF2" OR ABSTRACT:"FGF2" OR TITLE:"FLJ30672" OR ABSTRACT:"FLJ30672") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF13, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetFGF2