FGF2
FGF2 (Fibroblast growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.
Overview
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signalling. Binds to integrin ITGAV:ITGB3.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Quizartinib. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes clinical 0.62, affected pathway 0.99, literature 0.99, genetic association 0.00, animal model 0.55).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FGF2 (Fibroblast growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.
- 1 · What it is
FGF2 (Fibroblast growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.
- 2 · What goes wrong in cancer
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signalling.
- 3 · How drugs use it
No product in this corpus aims at FGF2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3676 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P09038 (protein name, function text, keywords and locations (REST API)); CIViC gene FGF2 (1 evidence items, 0 assertions, 1 variants; diseases: Acute Myeloid Leukaemia (GraphQL API, CC0)); Open Targets ENSG00000138685 (association with cancer (MONDO_0004992) 0.71; (GraphQL API, CC0))
Biology
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signalling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Location: Secreted; Nucleus (UniProt). Locus 4q28.1 (HGNC).
- Acute myeloid leukaemia: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.62; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FGF2" OR ABSTRACT:"FGF2" OR TITLE:"fibroblast growth factor 2" OR ABSTRACT:"fibroblast growth factor 2" OR TITLE:"Fibroblast growth factor 2" OR ABSTRACT:"Fibroblast growth factor 2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF2, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetFGF13