FOXF1
FOXF1 (Forkhead box protein F1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Overview
Probable transcription activator for a number of lung-specific genes.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Bevacizumab.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FOXF1 (Forkhead box protein F1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 1 · What it is
FOXF1 (Forkhead box protein F1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Probable transcription activator for a number of lung-specific genes. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at FOXF1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:3809 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q12946 (protein name, function text, keywords and locations (REST API)); CIViC gene FOXF1 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Biology
Probable transcription activator for a number of lung-specific genes. Location: Nucleus (UniProt). Locus 16q24.1 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FOXF1" OR ABSTRACT:"FOXF1" OR TITLE:"forkhead box F1" OR ABSTRACT:"forkhead box F1" OR TITLE:"Forkhead box protein F1" OR ABSTRACT:"Forkhead box protein F1" OR TITLE:"FREAC1" OR ABSTRACT:"FREAC1" OR TITLE:"FKHL5" OR ABSTRACT:"FKHL5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXF1, not a curated reading list.