FOXR2
FOXR2 (Forkhead box protein R2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
UniProt has no function text for Q6PJQ5; HGNC names it "forkhead box R2".
CIViC holds 3 clinical evidence items and 2 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FOXR2 (Forkhead box protein R2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
FOXR2 (Forkhead box protein R2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
UniProt has no function text for Q6PJQ5; HGNC names it "forkhead box R2". Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at FOXR2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:30469 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6PJQ5 (protein name, function text, keywords and locations (REST API)); CIViC gene FOXR2 (3 evidence items, 2 assertions, 1 variants; diseases: CNS Neuroblastoma With FOXR2 Activation (GraphQL API, CC0))
Biology
UniProt has no function text for Q6PJQ5; HGNC names it "forkhead box R2". Location: Nucleus (UniProt). Locus Xp11.21 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: CNS Neuroblastoma With FOXR2 Activation.
Latest papers
topQuery for this target: (TITLE:"FOXR2" OR ABSTRACT:"FOXR2" OR TITLE:"forkhead box R2" OR ABSTRACT:"forkhead box R2" OR TITLE:"Forkhead box protein R2" OR ABSTRACT:"Forkhead box protein R2" OR TITLE:"MGC21658" OR ABSTRACT:"MGC21658" OR TITLE:"FOXN6" OR ABSTRACT:"FOXN6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXR2, not a curated reading list.