GOLGB1
GOLGB1 (Golgin subfamily B member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
May participate in forming intercisternal cross-bridges of the Golgi complex.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.27, affected pathway 0.95, animal model 0.69, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GOLGB1 (Golgin subfamily B member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
GOLGB1 (Golgin subfamily B member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May participate in forming intercisternal cross-bridges of the Golgi complex. Location: Golgi apparatus membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at GOLGB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4429 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14789 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000173230 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Biology
May participate in forming intercisternal cross-bridges of the Golgi complex. Location: Golgi apparatus membrane (UniProt). Locus 3q13.33 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GOLGB1" OR ABSTRACT:"GOLGB1" OR TITLE:"golgin B1" OR ABSTRACT:"golgin B1" OR TITLE:"Golgin subfamily B member 1" OR ABSTRACT:"Golgin subfamily B member 1" OR TITLE:"GCP372" OR ABSTRACT:"GCP372" OR TITLE:"giantin" OR ABSTRACT:"giantin" OR TITLE:"GOLIM1" OR ABSTRACT:"GOLIM1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GOLGB1, not a curated reading list.