GOPC
GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.31, animal model 0.39, genetic association 0.04, somatic mutation 0.92).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels.
- 3 · How drugs use it
No product in this corpus aims at GOPC yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17643 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HD26 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000047932 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Biology
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes. Location: Cytoplasm; Golgi apparatus membrane; Golgi apparatus, trans-Golgi network membrane; Synapse (UniProt). Locus 6q22.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GOPC" OR ABSTRACT:"GOPC" OR TITLE:"golgi associated PDZ and coiled-coil motif containing" OR ABSTRACT:"golgi associated PDZ and coiled-coil motif containing" OR TITLE:"Golgi-associated PDZ and coiled-coil motif-containing protein" OR ABSTRACT:"Golgi-associated PDZ and coiled-coil motif-containing protein" OR TITLE:"dJ94G16.2" OR ABSTRACT:"dJ94G16.2" OR TITLE:"GOPC1" OR ABSTRACT:"GOPC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GOPC, not a curated reading list.