GSTP1
GSTP1 (Glutathione S-transferase P) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Ovarian cancer.
Overview
Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers.
CIViC holds 2 clinical evidence items and 0 assertions across 3 variants, naming Paclitaxel, Carboplatin, Cisplatin and FOLFOX Regimen.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GSTP1 (Glutathione S-transferase P) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Ovarian cancer.
- 1 · What it is
GSTP1 (Glutathione S-transferase P) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Ovarian cancer.
- 2 · What goes wrong in cancer
Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2).
- 3 · How drugs use it
No product in this corpus aims at GSTP1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:4638 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P09211 (protein name, function text, keywords and locations (REST API)); CIViC gene GSTP1 (2 evidence items, 0 assertions, 3 variants; diseases: Colorectal Cancer, Ovarian Carcinoma (GraphQL API, CC0))
Biology
Catalyses conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Location: Cytoplasm; Mitochondrion; Nucleus (UniProt). Locus 11q13.2 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
- Ovarian cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 4 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GSTP1" OR ABSTRACT:"GSTP1" OR TITLE:"glutathione S-transferase pi 1" OR ABSTRACT:"glutathione S-transferase pi 1" OR TITLE:"Glutathione S-transferase P" OR ABSTRACT:"Glutathione S-transferase P" OR TITLE:"FAEES3" OR ABSTRACT:"FAEES3" OR TITLE:"GST3" OR ABSTRACT:"GST3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GSTP1, not a curated reading list.