H1-5
H1-5 (Histone H1.5) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Overview
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibres and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · H1-5 (Histone H1.5) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 1 · What it is
H1-5 (Histone H1.5) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 2 · What goes wrong in cancer
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre.
- 3 · How drugs use it
No product in this corpus aims at H1-5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4719 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P16401 (protein name, function text, keywords and locations (REST API)); CIViC gene H1-5 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Biology
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibres and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Location: Nucleus; Chromosome (UniProt). Locus 6p22.1 (HGNC).
- Diffuse large B-cell lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"H1-5" OR ABSTRACT:"H1-5" OR TITLE:"H1.5 linker histone, cluster member" OR ABSTRACT:"H1.5 linker histone, cluster member" OR TITLE:"Histone H1.5" OR ABSTRACT:"Histone H1.5" OR TITLE:"H1b" OR ABSTRACT:"H1b" OR TITLE:"H1s-3" OR ABSTRACT:"H1s-3" OR TITLE:"H1F5" OR ABSTRACT:"H1F5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about H1-5, not a curated reading list.