HBB
HBB (Haemoglobin subunit beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Involved in oxygen transport from the lung to the various peripheral tissues. LVV-haemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signalling, these properties implicate it as a regulator of pain and inflammation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HBB (Haemoglobin subunit beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
HBB (Haemoglobin subunit beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Involved in oxygen transport from the lung to the various peripheral tissues. LVV-haemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.
- 3 · How drugs use it
No product in this corpus aims at HBB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4827 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P68871 (protein name, function text, keywords and locations (REST API)); CIViC gene HBB (1 evidence items, 0 assertions, 1 variants; diseases: SMARCB1-deficient Renal Medullary Carcinoma (GraphQL API, CC0))
Biology
Involved in oxygen transport from the lung to the various peripheral tissues. LVV-haemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signalling, these properties implicate it as a regulator of pain and inflammation. Locus 11p15.4 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: SMARCB1-deficient Renal Medullary Carcinoma.
Latest papers
topQuery for this target: (TITLE:"HBB" OR ABSTRACT:"HBB" OR TITLE:"hemoglobin subunit beta" OR ABSTRACT:"hemoglobin subunit beta" OR TITLE:"Hemoglobin subunit beta" OR ABSTRACT:"Hemoglobin subunit beta" OR TITLE:"CD113t-C" OR ABSTRACT:"CD113t-C" OR TITLE:"beta-globin" OR ABSTRACT:"beta-globin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HBB, not a curated reading list.