HBEGF
HBEGF (Proheparin-binding EGF-like growth factor) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.95, genetic association 0.00, clinical 0.08).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HBEGF (Proheparin-binding EGF-like growth factor) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
HBEGF (Proheparin-binding EGF-like growth factor) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function.
- 3 · How drugs use it
No product in this corpus aims at HBEGF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3059 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99075 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000113070 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 5q31.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.08. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HBEGF" OR ABSTRACT:"HBEGF" OR TITLE:"heparin binding EGF like growth factor" OR ABSTRACT:"heparin binding EGF like growth factor" OR TITLE:"Proheparin-binding EGF-like growth factor" OR ABSTRACT:"Proheparin-binding EGF-like growth factor" OR TITLE:"HB-EGF" OR ABSTRACT:"HB-EGF" OR TITLE:"HEGFL" OR ABSTRACT:"HEGFL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HBEGF, not a curated reading list.