HOXA11
HOXA11 (Homeobox protein Hox-A11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.99, animal model 0.43, genetic association 0.10, somatic mutation 0.93).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HOXA11 (Homeobox protein Hox-A11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
HOXA11 (Homeobox protein Hox-A11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at HOXA11 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:5101 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31270 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000005073 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 7p15.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HOXA11" OR ABSTRACT:"HOXA11" OR TITLE:"homeobox A11" OR ABSTRACT:"homeobox A11" OR TITLE:"Homeobox protein Hox-A11" OR ABSTRACT:"Homeobox protein Hox-A11" OR TITLE:"HOX1I" OR ABSTRACT:"HOX1I" OR TITLE:"HOX1" OR ABSTRACT:"HOX1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXA11, not a curated reading list.