HSPH1
HSPH1 (Heat shock protein 105 kDa) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Colorectal cancer.
Overview
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
CIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Fluorouracil, Oxaliplatin and Cisplatin.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HSPH1 (Heat shock protein 105 kDa) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Colorectal cancer.
- 1 · What it is
HSPH1 (Heat shock protein 105 kDa) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer and Colorectal cancer.
- 2 · What goes wrong in cancer
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release.
- 3 · How drugs use it
No product in this corpus aims at HSPH1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:16969 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92598 (protein name, function text, keywords and locations (REST API)); CIViC gene HSPH1 (3 evidence items, 0 assertions, 2 variants; diseases: Gastric Adenocarcinoma, Colorectal Cancer (GraphQL API, CC0))
Biology
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. Location: Cytoplasm (UniProt). Locus 13q12.3 (HGNC).
- Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease
- Colorectal cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HSPH1" OR ABSTRACT:"HSPH1" OR TITLE:"heat shock protein family H Hsp110 member 1" OR ABSTRACT:"heat shock protein family H Hsp110 member 1" OR TITLE:"Heat shock protein 105 kDa" OR ABSTRACT:"Heat shock protein 105 kDa" OR TITLE:"HSP105B" OR ABSTRACT:"HSP105B" OR TITLE:"KIAA0201" OR ABSTRACT:"KIAA0201" OR TITLE:"HSP105A" OR ABSTRACT:"HSP105A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSPH1, not a curated reading list.