IFNA2
IFNA2 (Interferon alpha-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
Produced by macrophages, IFN-alpha have antiviral activities.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.96, clinical 0.81).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · IFNA2 (Interferon alpha-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
IFNA2 (Interferon alpha-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Produced by macrophages, IFN-alpha have antiviral activities. Location: Secreted (UniProt).
- 3 · How drugs use it
No product in this corpus aims at IFNA2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:5423 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01563 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000188379 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
Produced by macrophages, IFN-alpha have antiviral activities. Location: Secreted (UniProt). Locus 9p21.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.81. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"IFNA2" OR ABSTRACT:"IFNA2" OR TITLE:"interferon alpha 2" OR ABSTRACT:"interferon alpha 2" OR TITLE:"Interferon alpha-2" OR ABSTRACT:"Interferon alpha-2" OR TITLE:"IFN-alphaA" OR ABSTRACT:"IFN-alphaA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IFNA2, not a curated reading list.