IGF2
IGF2 (Insulin-like growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Ovarian cancer and Pancreatic ductal adenocarcinoma.
Overview
The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development.
CIViC holds 5 clinical evidence items and 0 assertions across 1 variant, naming Linsitinib, Cabazitaxel, Ganitumab and Docetaxel and others.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · IGF2 (Insulin-like growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Ovarian cancer and Pancreatic ductal adenocarcinoma.
- 1 · What it is
IGF2 (Insulin-like growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Ovarian cancer and Pancreatic ductal adenocarcinoma.
- 2 · What goes wrong in cancer
The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals.
- 3 · How drugs use it
No product in this corpus aims at IGF2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:5466 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01344 (protein name, function text, keywords and locations (REST API)); CIViC gene IGF2 (5 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer, Ovarian Cancer, Pancreatic Adenocarcinoma (GraphQL API, CC0))
Biology
The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Location: Secreted (UniProt). Locus 11p15.5 (HGNC).
- Prostate cancer: CIViC evidence names this disease
- Ovarian cancer: CIViC evidence names this disease
- Pancreatic ductal adenocarcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; CIViC holds 5 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"IGF2" OR ABSTRACT:"IGF2" OR TITLE:"insulin like growth factor 2" OR ABSTRACT:"insulin like growth factor 2" OR TITLE:"Insulin-like growth factor 2" OR ABSTRACT:"Insulin-like growth factor 2" OR TITLE:"FLJ44734" OR ABSTRACT:"FLJ44734" OR TITLE:"IGF-II" OR ABSTRACT:"IGF-II" OR TITLE:"C11orf43" OR ABSTRACT:"C11orf43") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IGF2, not a curated reading list.